Amy Ikui’s laboratory studies DNA replication and cell division using S. cerevisae and Chlamydomonas reinhardtii as a model system, with the goal of understanding the molecular mechanism of cell growth control.
We aim to understand how cell cycle misregulation is linked to genome instability,
which is relevant to tumorigenesis and cancer in higher eukaryotes.
Areas of Expertise:
Project 1: DNA replication control by CDK and PP2A in S. cerevisiae (Jasmin)
Project 2: A role of PP2A during replication stress (Shoily)
Project 3: A role of cell wall integrity pathway in cell size (Stephen and Lea)
Project 4: A mechanism of DNA replication and cell cycle in Chlamydomonas reinhardtii (Noriko and Amy)